QTOF Mass Spectrometry
Since its first commercial launch 25 years ago, quadrupole time-of-flight (QTOF) mass spectrometry (MS) has revolutionized numerous fields, ranging from biological and pharmaceutical research to clinical toxicology. The unique hybridization of quadrupole and TOF technology resulted in high-resolution, high mass accuracy analysis of all ions simultaneously, which is today used to identify and quantify complex mixtures or unknown compounds.
The MS/MS capabilities of QTOF MS systems enable coupling to both LC and GC systems and Bruker’s expertise provides a variety of innovative instruments. Our powerful, high performance products are specifically designed to meet the rapidly growing needs of customers in the academic, pharmaceutical, industrial, clinical, and applied markets.
Instant expertise in accurate mass LC-MS/MS
Research-grade technology applied to every routine analytical task. The Bruker compact QTOF features:
- Low picogram sensitivity while delivering, highly precise MS and MS/MS data
- Definitive trace analysis from complex, high-background matrices, by increased dynamic range
- True Isotopic Pattern for unambiguous spectra
- Superior 1 ppm mass accuracy ensured by automated calibration
- 50 GBit/sec sampling technology maintaining full specification resolution even during ultrafast chromatography
The compact combines the robustness of Bruker orthogonal Time-of-Flight (TOF) instruments with 10-bit digitizer technology that allows for compound detection and identification across an unrivaled dynamic range.
High Dynamic Range
compact offers five orders of magnitude intrascan dynamic range at ultra high performance liquid chromatography (UHPLC) speed . Fast detection and digitizing technology is key to maintaining full resolution at all acquisition speeds and providing high dynamic range to detect the smallest peaks in the presence of a high-abundance background matrix.
GBT's Innovative Mass Spectrometry Solutions
Innovations such as Trapped Ion Mobility (TIMS), smartbeam and scanning lasers for MALDI-MS Imaging that deliver true pixel fidelity, and eXtreme Resolution FTMS (XR) technology capable to reveal Isotopic Fine Structure (IFS) signatures are pushing scientific exploration to new heights. Our mass spectrometry solutions enable scientists to make breakthrough discoveries and gain deeper insights.
GBT product lines which are represented here below include the following technologies: timsTOF, MRMS, rapifleX® MALDI-TOF/TOF, UHR-QTOF, Triple Quadrupole, HDX Solution, Toxtyper® and TargetScreener HR. Our industry leading software solutions such as SCiLS™ Lab for MS Imaging, MetaboScape® and Biopharma Compass® are examples for our solutions doing the work for you.
MALDI-TOF and TOF/TOF MS
The analytical advantages of matrix assisted laser desorption ionization (MALDI) TOF MS have been demonstrated for more than 25 years. With inherent benefits including its speed (time to results) and application flexibility, the convenience and effectiveness of MALDI-TOF MS is magnified by virtue of its low sample volume requirements and broad sample content (salts, buffers) amenability. Dramatic increases in the depth of MALDI analyses have been made routine by intuitive software, and easy automation allows for high throughput solutions.
Bruker’s FLEX series instruments provide reliable results from a market leading technology platform - well-known for outstanding performance, reliability, convenience and innovative design. From rapid screening to comprehensive target characterization, MALDI-TOF MS offers broad utility to meet all laboratory needs. Expert users and beginners can quickly and confidently tap into the analytical power and flexibility of Bruker’s FLEX series MALDI-TOF systems.
Trapped Ion Mobility Spectrometry (TIMS)
Ion mobility spectrometry (IMS) is a powerful analytical technique that has been widely applied over the last five decades, primarily in chemical physics and analytical chemistry applications. Only relatively recently has the potential of IMS coupled to MS (IMS-MS) been explored for the separation, identification and quantification of peptides and proteins
Magnetic Resonance Mass Spectrometry (MRMS)
Bruker’s scimaX® and solariX series instruments are powered by MRMS (Magnetic Resonance Mass Spectrometry) technology. Compared with common FTMS technologies, these instruments feature unmatched eXtreme Resolution (XR) and mass accuracy. This enables routine Isotopic Fine Structure (IFS) analysis or a broad mass range, resulting in unmatched confidence for compound identification.
solariX
The workhorse platform for high-field MRMS work at 12T or 15T – useful for ultra-complex mixture analysis such as petroleomics and dissolved organic materials.
scimaX®
scimaX® is powered by 2xR MRMS technology, bringing the "high hanging fruit" within easy reach
